Güncel Patoloji Dergisi 2019, Cilt 3, Sayı 3
The Role and Importance of Transbronchial Biopsy in the Diagnosis of Eosinophilic Lung Diseases
Nesrin GÜRÇAY 1, Funda DEMİRAĞ 1, Sema CANBAKAN 2, Saliha YILMAZ 2
1 Ankara Atatürk Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi, Patoloji Kliniği, ANKARA
2 Ankara Atatürk Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi, Göğüs Hastalıkları Kliniği, ANKARA
DOI : 10.5146/jcpath.2019.61 Aim: Eosinophilic lung diseases are infectious and noninfectious pulmonary conditions that involve eosinophil infiltration into the lung parenchyma with accompanying blood eosinophilia. We evaluated a case of chronic eosinophilic pneumonia with clinical, radiological and histopathological findings in transbronchial biopsy specimens.

Case: A 21-year-old female patient visited chest diseases department of our hospital because of shortness of breath. Bilateral pneumonic infiltrations on chest radiograph and high resolution computed tomography (HRCT) showed focal aeration elevations in both lungs, parenchymal density differences, and interlobular septal and peribronchial thickening. Transbronchial biopsy was performed due to peripheral blood eosinophilia 10%, total IgE 656 IU / ml and bronchoalveolar lavage (BAL) eosinophil rate was 28% in laboratory findings. Microscopic examination revealed intra-alveolar macrophage accumulation, fibrin masses and eosinophil dominate mixed type inflammatory cell infiltration in the interstitium.

Conclusion: The diagnosis of pulmonary diseases with eosinophilia requires a multidisciplinary, clinical, radiological and pathological approach as well as other interstitial lung diseases. A well-sampled transbronchial biopsy that representing the damaged parenchyma is as helpful in diagnosis as video-assisted thoracoscopic (VATS) biopsy. Anahtar Kelimeler : Pulmonary eosinophlia, Transbronchial biopsy, Diagnostic approach