Güncel Patoloji Dergisi
2018, Cilt 2, Sayı 1
Papular Acantholytic Dyskeratosis of Vulva
1 Şehitkamil Devlet Hastanesi, Tıbbi Patoloji Bölümü, GAZIANTEP
2 Karadeniz Teknik Üniversitesi Tıp Fakültesi, Tıbbi Patoloji Anabilim Dalı, TRABZON
DOI : 10.5146/jcpath.2018.23 Aim: Papular acantholytic dyskeratosis is a rare, chronic skin disorder and clinicopathological entity. It usually manifests with skin-colored or whitish papules on the anogenital and genitocrural area. Clinically, this disease presents as a persistent papular lesion on the vulva of young women. Despite being persistent, it is asymptomatic.
2 Karadeniz Teknik Üniversitesi Tıp Fakültesi, Tıbbi Patoloji Anabilim Dalı, TRABZON
DOI : 10.5146/jcpath.2018.23 Aim: Papular acantholytic dyskeratosis is a rare, chronic skin disorder and clinicopathological entity. It usually manifests with skin-colored or whitish papules on the anogenital and genitocrural area. Clinically, this disease presents as a persistent papular lesion on the vulva of young women. Despite being persistent, it is asymptomatic.
Case: A 62-year-old female patient was found to have a 0,3 cm single, bullous lesion over the right labium majus. Histopathological examination revealed hyperkeratosis and acanthosis as well as acantholysis and dyskeratotic cells forming corps rond and grains. Papular acantholytic dyskeratosis was diagnosed with histopathological and clinical findings.
Conclusion: Differential diagnosis includes mainly Hailey-Hailey and Darier"s diseases as well as verrucous dyskeratoma and Grover"s disease. Clinical features of the lesion, presents in a localized or generalized form, family history and genetic mutations are important in differential diagnosis.
Anahtar Kelimeler : Dyskeratosis, Anogenital, Genitocrural, Papular acantholytic dyskeratosis