Güncel Patoloji Dergisi 2017, Cilt 1, Sayı 3
Evaluation of HPV And p16 Expression in the Cervical Intraepithelial Neoplasia
Elife KIMILOĞLU 1, Özgecan GÜNDOĞAR 1, Feyza DEMİR 2, Zuhal ÖZCAN 3, Merve CİN 1, Nusret ERDOĞAN 1
1 GOP Taksim Eğitim ve Araştırma Hastanesi, Tıbbi Patoloji Bölümü, İSTANBUL
2 Van Yüzüncü Yıl Üniversitesi Tıp Fakültesi,Tıbbi Patoloji Anabilim Dalı, VAN
3 Haydarpaşa Numune Eğitim ve Araştırma Hastanesi,Patoloji Kliniği, İSTANBUL
DOI : 10.5146/jcpath.2017.12 Aim: Cervical carcinoma is still one of the leading causes of mortality in women worldwide despite the preventing programmes. The aim of this study is to evaluate the comparison of results of the cytology and histopathology in cervical intraepithelial neoplasia and squamous cell carcinoma cases and to confirm the presence of HPV-HR and p16.

Materials and Methods: We evaluated fifty one cases of cervical intraepithelial neoplasia and squamous cell carcinoma cases with their cytology results. HPV-HR was assesed by silver insitu hybridization and p16 immunohistochemical expressions in cervical intraepithelial neoplasia and squamous cell carcinoma cases.

Results: The level of CIN showed a significant difference for cytological results. Cases with a cytological diagnosis of atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion and high-grade squamous intraepithelial lesion had more CIN II and CIN III diagnosis in their histological materials. Histopathological types showed statistically significant difference for HR-HPV levels. p16 positive staining was detected in 35% of CIN I, 93.3% of CIN II, 92.9% of CIN III, and 100% of squamous cell carcinoma cases.

Conclusion: For the early diagnosis and treatment of cervical intraepithelial neoplasia; HPV-HR which is assessed by silver in situ hybridization and expression of p16 immunohistochemistry and the cytological results are important and necessary. Anahtar Kelimeler : Cervix, Cytology, Histopathology, HPV-HR, p16