Güncel Patoloji Dergisi 2019, Cilt 3, Sayı 1
Sebaceous Carcinoma In Situ: A Case Report
Taha Cumhan ŞAVLI 1, Cem LEBLEBICI 1, Ayşe Esra KOKU AKSU 2
1 İstanbul Eğitim ve Araştırma Hastanesi, Patoloji Bölümü, İSTANBUL
2 İstanbul Eğitim ve Araştırma Hastanesi, Dermatoloji Bölümü, İSTANBUL
DOI : 10.5146/jcpath.2019.44 Aim: Sebaceous carcinoma (SC) is an aggressive neoplasm that typically originates from the sebaceous glands in the ocular region. Pure sebaceous carcinoma in situ (SCis) is a rare and ill-defined entity.

Case: A 91-year-old female patient applied to our dermatology clinic with rash on the right cheek. She has noticed it for the last one year. Excisional biopsy was performed after punch biopsy. Clinical diagnoses were actinic keratosis and squamous cell carcinoma. On histopathological examination, atypical epithelial cell proliferation resembling basaloid germinative cells which displayed connection to the overlying epidermis was observed. These cells formed intraepidermal lobular arrangements which invaginated into the superficial dermis. Fine vacuoles suggesting sebaceous differentiation in some cell cytoplasm and scalloped nuclei were noted. Numerous mitoses were observed. No invasive tumor area was present. In the immunohistochemical study, diffuse and strong positive staining was detected with EMA and androgen receptor.

Conclusion: SCis can be interpreted clinically and microscopically as actinic keratosis or squamous cell carcinoma in situ (SCCis). It may be accompanied by Muir Torre Syndrome and therefore, being aware of the existence of this entity is important to avoid misdiagnosis. Anahtar Kelimeler : Sebaceous carcinoma, Sebaceous carcinoma in situ, Sebaceous differentiation, Muir Torre Syndrome