Güncel Patoloji Dergisi 2018, Cilt 2, Sayı 1
The Impact of Squalene on Disease Models
1 Dokuz Eylül Üniversitesi Tıp Fakültesi Hastanesi, Tıbbi Patoloji Anabilim Dalı, BALÇOVA, İZMİR
DOI : 10.5146/jcpath.2018.18 Squalene (C30H50), an isoprenoid compound, is synthesized in the liver and skin. Most important sources of squalene are olive oil and shark liver.

Squalene emulsions are used as adjuvant in vaccines, in the treatment of cancer and some other diseases due to their protective and preventive effects and in various fields as medicines and gene carriers.

Although Turkey is the 4th in the world for squalene production in 2014, there is no research in our country about the effects of this compound. Most of the literature of squalene is based on Spain and Italy, which are the forerunners in the production of olive oil.

Researches can be classified in two groups; related to the antioxidant effects and antitumor effects of squalene. Antioxidant investigations include efficacy on ulcerative colitis, myocardial infarction, Parkinson"s disease, drug and radiotherapy side effects. Antitumor effects were investigated in colon, lung, breast and skin cancers and neuroblastoma.

The review provides comprehensive information on squalene, including the laboratory and pathological methodologies and results of current studies. Effectiveness of squalene in many areas have not yet been researched and it seems that squalene should be a leading research topic for Turkey as a particularly important producer. Anahtar Kelimeler : Squalene, Olive oil, Antioxidant, Antitumor