2 Dokuz Eylül Üniversitesi Tıp Fakültesi, Tıbbi Patoloji Anabilim Dalı, İZMİR
3 Rize Eğitim ve Araştırma Hastanesi, Patoloji Kliniği, RİZE
4 S.B. İstanbul Eğitim ve Araştırma Hastanesi, Patoloji Kliniği, İSTANBUL
5 Ege Üniversitesi Tıp Fakültesi, Tıbbi Patoloji Anabilim Dalı, İZMİR
6 Şifa Üniversitesi Tıp Fakültesi, Tıbbi Patoloji Anabilim Dalı, İZMİR
DOI : 10.5146/jcpath.2017.14 Aim: In this study our goal is to investigate the incidence, causes and relationship with the prognostic parameters of granulomatous reaction in clear cell renal cell carcinomas.
Materials and Methods: The frequency of granulomatous reaction was analyzed in 389 renal cell carcinoma specimens from 5 different centers. The cause of granulomatous reaction, relationship between granulomatous reaction and pathologic prognostic parameters were analyzed.
Results: Granulomatous reaction was observed in 11 of the 389 patients. Granulomas were localized in the tumor stroma without necrosis. There was no significant correlation between the presence of granulomatous reaction and the other prognostic factors like age, gender, tumor size, tumor stage and Fuhrman degree.
Conclusion: The presence of granulomatous reaction in the tumor stroma in clear cell renal cell carcinomas in nephrectomy specimens is rare. In this small series, the presence of granulomas in clear cell renal cell carcinoma seems not to be related with prognosis.
Anahtar Kelimeler : Clear cell renal cell carcinoma, Nephrectomy, Granuloma