Güncel Patoloji Dergisi
2017, Cilt 1, Sayı 1
Micropapillary Carcinoma: Pathogenesis, Histological and Clinical Features
1 S.B. İstanbul Eğitim ve Araştırma Hastanesi, Patoloji Kliniği, İSTANBUL
DOI : 10.5146/jcpath.2017.04 Invasive micropapillary carcinoma is a rare variant of carcinoma which was first described in 1993. It has been recognized in various anatomic sites including breast, urinary bladder, lung, salivary glands and ovary, since then. Histologically, it is characterized by tight clusters of neoplastic cells and clear spaces around them resembling lymphatic vessels. Micropapillary growth patern is usually mixed with conventional carcinoma or other variants of carcinoma. Pure micropapillary carcinoma is very rare. Tumors with micropapillary growth pattern tend to make lymphovascular invasion, lymph node metastasis and distant metastasis more frequently than conventional carcinomas. Furthermore, patients present with high-stage disease and have poor prognosis compared to patients with conventional carcinoma of the same organ. Recognition of this aggressive type of carcinoma is important for treatment choice and clinical follow-up of the patient. This review discusses the pathogenesis, clinical, morphological, and immunohistochemical features of micropapillary carcinoma of various organs/sites. Anahtar Kelimeler : Micropapillary carcinoma, Pathogenesis, Immunohistochemistry, Clinical features, Treatment
DOI : 10.5146/jcpath.2017.04 Invasive micropapillary carcinoma is a rare variant of carcinoma which was first described in 1993. It has been recognized in various anatomic sites including breast, urinary bladder, lung, salivary glands and ovary, since then. Histologically, it is characterized by tight clusters of neoplastic cells and clear spaces around them resembling lymphatic vessels. Micropapillary growth patern is usually mixed with conventional carcinoma or other variants of carcinoma. Pure micropapillary carcinoma is very rare. Tumors with micropapillary growth pattern tend to make lymphovascular invasion, lymph node metastasis and distant metastasis more frequently than conventional carcinomas. Furthermore, patients present with high-stage disease and have poor prognosis compared to patients with conventional carcinoma of the same organ. Recognition of this aggressive type of carcinoma is important for treatment choice and clinical follow-up of the patient. This review discusses the pathogenesis, clinical, morphological, and immunohistochemical features of micropapillary carcinoma of various organs/sites. Anahtar Kelimeler : Micropapillary carcinoma, Pathogenesis, Immunohistochemistry, Clinical features, Treatment